Despite overall declines in rates of aggressive prostate cancer (PCa) in the U.S., racial disparity persists, with African American (AA) men experiencing rates greater than 2X those for European American (EA) men. While prostate specific antigen (PSA) screening has made a major contribution to the mortality decline, new screening strategies are needed to identify potentially lethal cancer while limiting risks. The overall goal of this project is to obtain reliable age-adjusted estimates of the distribution of Prostate Health Index (PHI) in healthy AA men, and compare this distribution to the PHI distribution of AA men with negative prostate biopsies and men with indolent and non-indolent PCa. This will provide evidence for the potential of the PHI score to be used as a PCa screening test to replace PSA. Our hypothesis is that PHI will have different distributions in AA men with benign prostatic disease, malignant prostatic disease and healthy controls. We propose to recruit a cohort of 100 healthy control AA men age 30-69y/o without prostate cancer to establish normal age-adjusted ranges for PHI and compare distributions of PHI scores and their components in AA healthy controls, in AA men with negative prostate biopsies and in AA men with PCa.

Related Pages

Community Engagement Core »

Enhancing community engagement, cancer education, survivorship support, and community capacity building.

Research Education Core »

We leverage the strengths of ChicagoCHEC institutions and partners to support students, trainees, and faculty.

Planning and Evaluation Core »

We initiate new projects and continuously evaluate ChicagoCHEC’s impact and progress toward its mission to advance cancer health equity via scientific discovery, education, training, and community engagement.

Admin Core »

The Admin Core supports ChicagoCHEC’s research, education, and outreach via overall leadership, administrative management, and program coordination.

Choose to Change Research Project »

Reducing Tobacco Use Disparities Among Adults in Safety Net Community Health Centers (The Choose to Change Study)

WeCanConnect Pilot Project »

WeCanConnect: Using mHealth to Connect Physically Disabled Cancer Patients with Matched Disabled Survivors

Mi Guia (My Guide) pilot study »

An e-Health Intervention to Improve Symptom Burden and Health-Related Quality of Life among Hispanic Women Completing Active Treatment for Breast Cancer

Latino Obesity Project »

Community-engaged obesity intervention development for Puerto Rican and Mexican men

Prostate Cancer Disparity Project »

Prostate cancer disparity in Chicago-area African American men: patient-derived models and biomarkers of cancer risk

Reducing Colorectal Cancer Disparities »

Reducing colorectal cancer disparities on the South Side of Chicago through cross-Institutional collaborations

Breast Cancer Disparities in Chicago: Biological Factors »

The goal of this research proposal is to address the biological underpinnings of breast cancer mortality disparities in Chicago. African […]